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Gut Peptides and Bone Remodeling in Children With Neuromuscular Disorders
Sponsor: University of Copenhagen
Summary
Both GIP and GLP-2 reduce bone resorption (measured as CTX) in healthy adult individuals. In this study, we will investigate whether GIP and GLP-2 reduce CTX in children with spinal muscular atrophy, duchenne muscular dystrophy, or cerebral palsy.
Key Details
Gender
All
Age Range
10 Years - 17 Years
Study Type
INTERVENTIONAL
Enrollment
8
Start Date
2023-03-24
Completion Date
2026-12
Last Updated
2025-11-28
Healthy Volunteers
No
Interventions
Meal test
Ingestion of an oral liquid meal (nutridrink), 3.3 mL/kg body weight.
GIP + GLP-2
Subcutaneous GIP + GLP-2 injection (1 mL containing 100 microgram GIP + 1 mL containing 400 microgram GLP-2).
Placebo
Subcutaneous saline injection (2 mL isotonic saline).
Locations (1)
Rigshospitalet
Copenhagen, Denmark