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Mechanisms Underlying the Nocibo Effect of Contagious Itch. in Both Histaminergic and Nonhistaminergic Itch
Sponsor: Aalborg University
Summary
The study consists of one experimental session of approximately 1½ hours. The participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. Afterwards, three areas will be selected on each forearm of the subjects. Two areas will be treated with histamine, two with cowhage, and two with vehicle. One application of each substance will be conducted including the contagious itch component. During the 10 minutes of the application of the pruritogens, itch and pain will be continuously monitored using a VAS scale.
Official title: Pain and Itch Neuromodulation: Effects of Offset Analgesia, Placebo, and Nocebo and Topographical Distribution of Itch and Pain Receptors
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-12-01
Completion Date
2028-12-31
Last Updated
2025-12-04
Healthy Volunteers
Yes
Conditions
Interventions
Histamine
To deliver histamine, standard allergy skin prick test (SPT) lancets are applied
Cowhage (Mucuna Pruriens)
The spicules will be manually inserted. Approximately 30-35 spicules are gently rubbed into a 1 cm diameter skin area on the forearm/face
Placebo
To deliver steril water, standard allergy skin prick test (SPT) lancets are applied
Locations (1)
Aalborg University
Gistrup, Denmark, Denmark