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Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.
Sponsor: Dalia Mohamed Salah
Summary
The aim of the study is to 1. Evaluate the preventive value of Lactoferrin on VAP among ventilated neonates. 2. Evaluate the Primary outcome of Lactoferrin on: Sepsis, Feeding intolerance, Vomiting, Constipation or diarrhea 3. Evaluate the effect of Lactoferrin in critically ventilated neonates on: Incidence of VAP Duration of mechanical ventilation Duration of hospital stay
Key Details
Gender
All
Age Range
0 Days - 90 Days
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-08-01
Completion Date
2026-11-01
Last Updated
2026-10-06
Healthy Volunteers
No
Conditions
Interventions
Lactoferrin in prevention of VAP
oral dose separate from feeds \[at a daily dose of 100mg/day\] via orogastric tube from first day of enrollment till time of successful extubation plus standard preventive measures of VAP; these include semi recumbent position, hand washing, suctioning when needed, endotracheal tube with subglottic secretion drainage, using heat and moisture exchanger filter, oral hygiene, changing of tubes only when needed and changing of ventilator circuit every 5 days.
Control
They will receive standard preventive VAP strategies only.
Locations (1)
Neonatal Intensive Care Unit, Tanta University Children's Hospital
Tanta, Egypt