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Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Sponsor: Centre Hospitalier Universitaire Dijon
Summary
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
60
Start Date
2026-01-26
Completion Date
2027-01
Last Updated
2026-01-29
Healthy Volunteers
Yes
Conditions
Interventions
Skin samples
* Scleroderma group: skin biopsy for scleroderma patients * Control group: recovery of resected tissue from patients undergoing plastic, reconstructive and aesthetic surgery.
Analysis of fibroblasts
Analysis of samples by RNA sequencing
Locations (1)
CHU Dijon Bourgogne
Dijon, France