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A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
Sponsor: Janssen Research & Development, LLC
Summary
The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.
Official title: A Phase 3 Randomized Study Comparing JNJ-79635322 and an Anti-BCMAxCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma Who Have Received at Least 3 Prior Lines of Therapy Including a PI, an IMiD, and an Anti CD38 Antibody
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
400
Start Date
2026-02-04
Completion Date
2031-09-30
Last Updated
2026-03-19
Healthy Volunteers
No
Conditions
Interventions
JNJ-79635322
JNJ-79635322 will be administered as SC injection.
Teclistamab
Teclistamab will be administered as SC injection.
Locations (33)
USC Norris Comprehensive Cancer Center
Los Angeles, California, United States
University of Connecticut Health Center
Farmington, Connecticut, United States
Yale Cancer Center
New Haven, Connecticut, United States
Florida Cancer Specialists & Research Institute
Fort Myers, Florida, United States
Emory University
Atlanta, Georgia, United States
Norton Cancer Institute
Louisville, Kentucky, United States
Mount Sinai Chelsea
New York, New York, United States
Icahn School of Medicine at Mount Sinai
New York, New York, United States
Memorial Sloan Kettering Cancer Center
New York, New York, United States
Durham VAMC
Durham, North Carolina, United States
Oregon Health And Science University
Portland, Oregon, United States
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States
Box Hill Hospital
Box Hill, Australia
Mater Misericordiae Ltd
Brisbane, Australia
St Vincents Hospital Melbourne
Fitzroy, Australia
The Alfred Hospital
Melbourne, Australia
Gold Coast University Hospital
Southport, Australia
Hospital De Clinicas De Porto Alegre
Porto Alegre, Brazil
Soroka Medical Center
Beersheba, Israel
Bnai Zion Medical Center
Haifa, Israel
Rambam Medical Center
Haifa, Israel
Carmel Medical Center
Haifa, Israel
Shaare Zedek MC
Jerusalem, Israel
Sheba Medical Center
Ramat Gan, Israel
Baruch Padeh MC
Ramat Poriya, Israel
Assuta MC
Tel Aviv, Israel
Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyō City, Japan
Chiba Cancer Center
Chiba, Japan
Shonan Kamakura General Hospital
Kamakura-shi, Japan
Kameda Medical Center
Kamogawa, Japan
Yamanashi Prefectural Central Hospital
Kofu, Japan
The Jikei University Hospital
Minato, Japan
Japanese Red Cross Medical Center
Shibuya City, Japan