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A Study of LY4213663 in Healthy Participants and Participants With Rheumatoid Arthritis
Sponsor: Eli Lilly and Company
Summary
The purpose of this study is to evaluate how well LY4213663 is tolerated and what side effects may occur in healthy participants and participants with rheumatoid arthritis (RA). The study drug will be administered either subcutaneously (SC) (under the skin) or intravenously (IV) (into a vein in the arm). Blood tests will be performed to investigate how the body processes the study drug and how the study drug affects the body. The study will last approximately 33 weeks excluding screening.
Official title: A Phase 1, Multicenter, Randomized, Placebo-Controlled, Investigator- and Participant-Blinded, Single- and Multiple-Ascending Dose Study to Evaluate Safety, Tolerability, and Pharmacokinetics of LY4213663 in Healthy Participants, and Two Open-Label, Multiple-Dose Evaluations of LY4213663 in Patients With Rheumatoid Arthritis.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
134
Start Date
2025-12-02
Completion Date
2028-03
Last Updated
2026-01-20
Healthy Volunteers
Yes
Conditions
Interventions
LY4213663
Administered SC
LY4213663
Administered IV
Placebo
Administered SC
Placebo
Administered IV
Locations (9)
Pinnacle Research Group, LLC
Anniston, Alabama, United States
Arizona Research Center
Phoenix, Arizona, United States
Clinical Research of West Florida, Inc. (Clearwater)
Clearwater, Florida, United States
GNP Research at Mark Jaffe, MD
Cooper City, Florida, United States
Fortrea Clinical Research Unit
Daytona Beach, Florida, United States
AGA Clinical Trials
Hialeah, Florida, United States
Advanced Pharma CR, LLC
Miami, Florida, United States
Floridian Clinical Research
Miami Lakes, Florida, United States
Oasis Clinical Research
Las Vegas, Nevada, United States