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Rapid Management of Resistant Hypertension in the Public Health System (Fast Control)
Sponsor: Instituto Dante Pazzanese de Cardiologia
Summary
This is a single-center, open-label, randomized clinical trial conducted at the Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil. The study evaluates a simplified treatment strategy for patients with apparent resistant hypertension, comparing fixed triple combination therapy (perindopril, indapamide, and amlodipine) with usual care using multiple separate antihypertensive drugs. The primary objective is to compare 24-hour blood pressure control as measured by ABPM at 12 weeks between the two treatment strategies. Enrollment began on July 15, 2023, and this study was registered retrospectively.
Official title: Strategy for Rapid Control of Apparent Resistant Arterial Hypertension in the Public Health System (FAST Control)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
142
Start Date
2023-07-15
Completion Date
2026-12-31
Last Updated
2025-12-02
Healthy Volunteers
No
Interventions
Triple Fixed-Dose Combination (Perindoprile/Indapamide/Amlodipine)
Participants receive a fixed-dose tablet containing perindopril 10 mg, indapamide 2.5 mg, and amlodipine 10 mg administered once daily for 12 weeks. Randomized participants in this group discontinue their previous antihypertensive medications and replace them with the single-pill triple fixed-dose combination. Treatment adjustments may be made if required according to office blood pressure measurements
Usual Care Antihypertensive Regimen
Participants continue their usual antihypertensive therapy, consisting of up to five drug classes administered as separate tablets. Medication types and doses are adjusted by the investigator as needed to achieve office blood pressure control, following standard clinical practice. Treatment modifications are permitted throughout the 12-week study period according to clinical judgment and blood pressure response.
Locations (1)
Instituto Dante Pazzanese de Cardiologia
São Paulo, São Paulo, Brazil