Clinical Research Directory

Inclusion Criteria: (MUST MEET ALL INCLUSION CRITERIA) * Patient with aged ≥18 years AND; * Patient have non-valvular atrial (NVAF) with a CHA2DS2-VASc score ≥2, and presented at least one high-bleeding-risk criterion according to the Munich consensus document AND; * Patient are required to undergo preprocedural TEE / CCTA to confirm the absence of LAA thrombus and to ensure that LAA anatomy is suitable for closure with either device. * Patient who has been informed of the characteristics of the study and has provided written informed consent.. Exclusion Criteria: (MUST NOT MEET ANY EXCLUSION CRITERIA) * Patient life expectancy \<1 year (terminal illness). * Patient with requirement for oral anticoagulation therapy for any indication other than non-valvular atrial fibrillation. * Patient with prior surgical ligation or obliteration of the left atrial appendage. * Patient with history of allergic reaction or intolerance to any material used in the study devices or to any of the antithrombotic agents required post-procedure. * Patient with active systemic infection. * Patient with concurrent participation in another investigational study that may affect study results. * Patient with inability or unwillingness to comply with the study protocol or follow-up requirements. * Patient pregnant or breastfeeding women.