Clinical Research Directory

Inclusion Criteria: * Individuals seeking IVF-ET fertility treatment; * Meeting the Bologna criteria for the definition of poor ovarian response (POR), specifically: * (1) Meeting 2 of the following 3 criteria: * ① Presence of high-risk factors for POR; * ② Previous cycle with ≤3 retrieved oocytes under a standard stimulation protocol; * ③ Abnormal ovarian reserve assessment: Antral follicle count (AFC) \<5 or Anti-Müllerian hormone (AMH) \<1.1 ng/mL. or * (2) Patients with normal age or ovarian reserve function who experience poor ovarian response (POR) after two consecutive cycles of maximum ovarian stimulation protocols; * BMI between 18.5-28.0 kg/m² * Voluntarily participate and sign an informed consent form. Exclusion Criteria: * Age ≥40 years; * Baseline FSH \>25 U/L; * Endocrine disorders (e.g., diabetes, thyroid disease) or autoimmune diseases (e.g., rheumatoid arthritis, lupus, Crohn's disease), chromosomal abnormalities, uterine malformations; * History of ovarian surgery; history of uterine surgery; adenomyosis; * History of more than 3 cycles of controlled ovarian stimulation (COS); * Male infertility; * Use within the past 3 months of medications that may affect ovarian reserve or ovarian responsiveness (e.g., oral contraceptives, glucocorticoids, antioxidant supplements, insulin sensitizers, DHEA, growth hormone, etc.); * Use of traditional Chinese medicine within the past 3 months; * Known allergy to Coenzyme Q10 or panthenol (water-soluble isomer of CoQ10); * PGT (Preimplantation Genetic Testing) population; * Acute or chronic renal insufficiency, hemodialysis treatment, history of severe renal impairment; * Infectious diseases such as HIV, active hepatitis, history of metabolic acidosis, tuberculosis; * Cardiovascular events within 3 months: coronary artery disease/myocardial infarction/clinically significant congestive heart failure; stroke/transient ischemic attack; deep vein thrombosis/pulmonary embolism; uncontrolled hypertension (systolic ≥160 mmHg or diastolic ≥90 mmHg); diagnosed diabetes; coronary intervention or coronary artery bypass graft surgery; * Neurological disorders such as dementia (e.g., Alzheimer's/Parkinson's) or use of related medications; * History of psychological/psychiatric disorders and use of antiepileptic, antidepressant, or similar medications; * History of cancer, radiation therapy, or chemotherapy; * Unwillingness to take supplements provided by this study; * Alcoholics, smokers, or individuals with substance dependence; * Participants in other clinical trials within the past month; * Patients deemed ineligible for enrollment by the investigator.