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N-acetylcysteine for Root Canal Treatment of Necrotic Teeth With Apical Periodontitis
Sponsor: Alexandria University
Summary
A randomized controlled trial comparing the postoperative pain intensity, periapical biomarkers level, and periapical healing in patients with necrotic mature teeth and apical periodontitis treated with N-acetylcysteine (NAC), as an intracanal and adjunctive systemic medication, versus calcium hydroxide (Ca(OH)₂) intracanal medication alone.
Official title: Evaluation of N-acetylcysteine as an Intracanal and Adjunctive Systemic Medication in Root Canal Treatment of Necrotic Mature Teeth With Apical Periodontitis: a Randomized Controlled Clinical Trial
Key Details
Gender
All
Age Range
16 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
40
Start Date
2025-11-15
Completion Date
2026-06
Last Updated
2025-12-30
Healthy Volunteers
No
Conditions
Interventions
Calcium hydroxide (Ca(OH)₂)
UltraCal XS calcium hydroxide (Ca(OH)₂) intracanal medication for 7 days
N-Acetylcysteine (NAC)
N-acetylcysteine (NAC) intracanal medication for 7 days and 600 mg/day oral NAC for 21 days
Locations (1)
Faculty of Dentistry, Alexandria University
Alexandria, Egypt