Clinical Research Directory
Browse clinical research sites, groups, and studies.
Predictive Value of Exosomes in Pleural Effusion for Advanced Lung Cancer
Sponsor: Fudan University
Summary
The goal of this observational study is to investigate the predictive value of exosome characteristics in patients with advanced non-small cell lung cancer (NSCLC) and malignant pleural effusion (MPE). The main question it aims to answer is: Can the long RNA profile of exosomes derived from plasma and malignant pleural effusion predict treatment response in patients with advanced NSCLC and MPE? Participants who are scheduled to receive standard systemic therapy (including immunotherapy, chemotherapy, or targeted therapy) as part of their regular medical care will be enrolled. Researchers will collect paired samples of peripheral blood and malignant pleural effusion at baseline and key time points during treatment to analyze the exosomal long RNA profiles and correlate them with treatment efficacy and survival outcomes.
Official title: Exosome Detection for Predicting Treatment Efficacy in Advanced NSCLC With Malignant Pleural Effusion
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2025-10-16
Completion Date
2030-10-16
Last Updated
2025-12-04
Healthy Volunteers
No
Locations (1)
Shanghai Cancer hospital of Fudan University
Shanghai, Shanghai Municipality, China