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Evaluation of Diaphragmatic Function After Interscalene Block With Liposomal Bupivacaine
Sponsor: Zhejiang University
Summary
The study aims to evaluation the effects of Liposomal Bupivacaine on diaphragmatic function in patients undergoing upper limb surgery who receive Interscalene Brachial Plexus Block. A total of 120 eligible patients will be enrolled and divided into two groups: Group A will receive 20ml of 0.5% Hydrochloride Bupivacaine , while Group B will receive 10ml of 0.5% Hydrochloride Bupivacaine plus 10ml of Liposomal Bupivacaine. Assessments of diaphragmatic function, pulmonary function, and pain intensity will be performed before the block and at different time points after the block, with follow-up for adverse events. The study is scheduled to run from September 2025 to September 2026, with strict adherence to privacy protection and ethical guidelines.
Official title: Evaluation of Diaphragmatic Function After Interscalene Brachial Plexus Block With Liposomal Bupivacaine: A Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-12-05
Completion Date
2026-12-20
Last Updated
2025-12-04
Healthy Volunteers
No
Conditions
Interventions
0.5% Hydrochloride Bupivacaine 20ml
0.5% Hydrochloride Bupivacaine 20ml for ISBPB
0.5% Hydrochloride Bupivacaine 10ml
0.5% Hydrochloride Bupivacaine 10ml for ISBPB
Liposomal Bupivacaine 10mL
Liposomal Bupivacaine 10mL for ISBPB
Locations (1)
The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, zhejiang 310000
Hangzhou, Zhejiang, China