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Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity
Sponsor: Blekinge Institute of Technology
Summary
The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are: * Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure? * What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity? Researchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure. Participants will: * Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA * Undergo pulmonary function tests and sampling of blod and urin before and after each session * Serve as their own controls in a double-blind, randomized, crossover study design
Official title: Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity - A Randomized Controlled Cross-Over Trial
Key Details
Gender
All
Age Range
20 Years - 64 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2026-01
Completion Date
2030-12
Last Updated
2025-12-04
Healthy Volunteers
Yes
Conditions
Interventions
Inhaled Hydrogen-Enriched Oxygen Gas
Participants will inhale a gas mixture consisting of 98-99% oxygen and 1-2% hydrogen via a breathing circuit during a single hyperbaric exposure. The exposure will be conducted at a partial pressure of 1.75 ATA for 240 minutes. The intervention aims to evaluate the protective effect of hydrogen gas against pulmonary oxygen toxicity.
Inhaled Nitrogen-Enriched Oxygen Gas
Participants will inhale a gas mixture consisting of 98-99% oxygen and 1-2% nitrogen via a breathing circuit during a single hyperbaric exposure. The exposure will be conducted at a partial pressure of 1.75 ATA for 240 minutes. The intervention aims to evaluate the protective effect of hydrogen gas against pulmonary oxygen toxicity.
Locations (2)
Blekinge Institute of Technology
Karlskrona, Blekinge County, Sweden
Swedish Armed Forces Diving and Naval Medicine Centre (DNC)
Karlskrona, Sweden