Clinical Research Directory

Inclusion Criteria: 1. 18 to 65 years old 2. Patients diagnosed with Major Depressive Disorder according to DSM 5 and the severity of their illness 3. Scoring 7 points or more on the Maudsley staging method 4. Having depression unresponsive to 2 different antidepressants 5. No clinical mental retardation 6. Agree to participate in the study 7. Hamilton Depression Rating Scale-17 \[HDRS\] score of 20 or higher 8. Montgomery Asberg Depression Rating Scale \[MADRS\] score of 20 or above 9. Being right hand dominant 10. Having used the same antidepressant at the same dose for the last 4 weeks Exclusion Criteria: 1. Diagnosed with a neurological or metabolic disease that affects cognitive functions (Systemic diseases such as diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease and malignancies) 2. Having a foreign body such as a pacemaker, intracranial implant that can magnetically interact 3. Hearing and visual impairments that prevent communication 4. Unstable or acute medical conditions 5. Pregnancy or breastfeeding 6. Having a primary psychiatric disorder other than major depressive disorder 7. Being diagnosed with severe MDD with psychotic features