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A Cell-free tsRNA Signature for Early Detection of Hepatocellular Carcinoma
Sponsor: City of Hope Medical Center
Summary
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a cell-free tsRNA (cf-tsRNA)-based liquid biopsy assay for accurate detection of early-stage HCC.
Official title: A Cell-Free tsRNA-Based Liquid Biopsy Signature for Early Detection of Hepatocellular Carcinoma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2025-01-15
Completion Date
2026-06-18
Last Updated
2025-12-10
Healthy Volunteers
Yes
Conditions
Interventions
Small RNA sequence
Comprehensive small RNA sequencing of serum or plasma-derived cf-tsRNAs to identify candidate biomarkers distinguishing HCC from NDC.
Rt-qPCR
Construction of integrated cf- tsmiRNAs diagnostic classifier using machine learning
Rt-qPCR
PCR-based validation of the tsRNA panel
Locations (1)
City of Hope Medical Center
Duarte, California, United States