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Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)
Sponsor: City of Hope Medical Center
Summary
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a multi-omics-based liquid biopsy assay, especially focusing on ncRNAs (e.g. tsRNA, miRNA, circRNA, lncRNA, etc.) for accurate detection of early-stage HCC.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
600
Start Date
2025-01-15
Completion Date
2028-06-18
Last Updated
2026-07-01
Healthy Volunteers
Yes
Conditions
Interventions
Small RNA sequence
Comprehensive small RNA sequencing of serum or plasma-derived cf-tsRNAs to identify candidate biomarkers distinguishing HCC from NDC.
Rt-qPCR
Construction of integrated cf- tsmiRNAs diagnostic classifier using machine learning
Rt-qPCR
PCR-based validation of the tsRNA panel
Locations (1)
City of Hope Medical Center
Duarte, California, United States