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SUCCESS Score Validation in Fuchs Dystrophy
Sponsor: Instituto Ramón y Cajal de Investigación Sanitaria
Summary
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal dystrophy (FECD). The model's performance and clinical utility are assessed using discrimination, calibration, and reclassification metrics.
Official title: Validation and Extension of the SUCCESS Score for Fuchs Dystrophy After Cataract Surgery
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
OBSERVATIONAL
Enrollment
250
Start Date
2020-06-01
Completion Date
2026-12
Last Updated
2025-12-04
Healthy Volunteers
No
Conditions
Interventions
Phacoemulsification Cataract Surgery
Standard phacoemulsification cataract surgery performed in patients with Fuchs endothelial corneal dystrophy (FECD). All procedures are carried out according to institutional protocols at participating tertiary centers. Preoperative Scheimpflug tomography and corneal densitometry measurements are collected to calculate the SUCCESS Score and evaluate the risk of postoperative endothelial decompensation. Postoperative outcomes are monitored to determine whether endothelial keratoplasty (EK) is required during follow-up.
Locations (1)
Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
Madrid, Madrid, Spain