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Single-cell Multiomics and Spatiotemporal Omics Analyze the Mechanism of Liver Degenerative Disease
Sponsor: Nanfang Hospital, Southern Medical University
Summary
The purpose of this observational study is to employ single-cell multi-omics and spatial omics technologies to characterize the spatial and immune structures within the livers of patients with fatty liver, hepatic hemangioma, focal nodular hyperplasia, liver fibrosis, cirrhosis, and HBV infection. The primary questions it aims to address are: Investigate the mechanisms of liver degenerative changes during the processes of liver aging, fatty liver, HBV infection, liver fibrosis, and cirrhosis. Characterize the molecular features and cellular networks at different stages of liver degeneration and identify new targets and mechanisms for the cure of the aforementioned diseases. The study will collect peripheral blood and discarded liver tissue from patients with hepatic hemangioma, fatty liver, HBV infection, liver fibrosis, and cirrhosis who are undergoing hepatectomy or liver biopsy.
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
240
Start Date
2023-03-01
Completion Date
2026-02-12
Last Updated
2025-12-05
Healthy Volunteers
Yes
Interventions
Collection of Preoperative Peripheral Blood
Prior to surgery, 30 milliliters of peripheral blood will be drawn from the subject's upper limb.
Collection of Discarded Liver Tissue During Surgery
From subjects undergoing hepatectomy or liver biopsy, discarded liver tissue will be collected during the surgical procedure.
Locations (1)
Nan
Guangzhou, Guangdong, China