Clinical Research Directory

Inclusion Criteria: 1. Patients 18 years of age or older 2. Underwent a major operative orthopaedic procedure Exclusion Criteria: 1. Contraindication for NSAIDs. 2. Preoperative chronic opioid use (preoperative use of \>14 days and average of \>30 Morphine Milligram Equivalents per day). 3. Active treatment for opioid use disorder. 4. Previous or current illicit drug use. 5. Major surgery for pathologic (cancer-related) condition. 6. Hand surgery. 7. Concurrent operative treatment by another specialty team. 8. Discharged to an extended medical care facility. 9. Incarceration. 10. Women who are pregnant or planning to become pregnant in the next 6 weeks. 11. Expected injury survival of less than 6 weeks. 12. Terminal illness with expected survival of less than 6 weeks. 13. Anticipated problems, in the judgment of research personnel, with maintaining follow-up with the patient. 14. Currently enrolled in a trial that does not permit co-enrollment. 15. Prior enrollment in the trial. 16. Unable to obtain informed consent. 17. Non-English speaking 18. Eligible patient was not approached prior to hospital discharge (missed participant). 19. Did not provide informed consent (declined participation). 20. Other reason to exclude the patient, as approved by the Principal Investigator