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Building Adaptive School-based Interventions for Caries
Sponsor: University of Pennsylvania
Summary
Dental caries (tooth decay) is the world's most prevalent noncommunicable disease. Current preventive and therapeutic treatments are available that can be provided in a school-based health service environment. However, not all children respond to care, and school programs can result in under- or over-treatment, leaving children at high risk. The Building Adaptive School-based Interventions for Caries (BASICS) study will identify the optimal sequence and intensity of these treatments to minimize nonresponse, creating adaptive interventions tailored to specific needs in order to personalize school-based dental medicine.
Official title: The Building Adaptive School-based Interventions for Caries Study (BASICS): A Phase III Sequential, Multiple-Assignment, Randomized Trial of Minimally Invasive Therapies to Reduce Treatment Nonresponse
Key Details
Gender
All
Age Range
5 Years - 13 Years
Study Type
INTERVENTIONAL
Enrollment
1200
Start Date
2026-09
Completion Date
2030-06
Last Updated
2026-03-02
Healthy Volunteers
Yes
Conditions
Interventions
Silver Diamine Fluoride (38%)
Topically applied silver diamine fluoride 38% solution
Glass Ionomer Sealant
GIC Dental Sealants
Fluoride Varnishes
Topically applied fluoride varnish (FV)
Hygiene Intervention
Behavioral intervention to improve dental hygiene