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NOT YET RECRUITING
NCT07265830
PHASE3

Building Adaptive School-based Interventions for Caries

Sponsor: University of Pennsylvania

View on ClinicalTrials.gov

Summary

Dental caries (tooth decay) is the world's most prevalent noncommunicable disease. Current preventive and therapeutic treatments are available that can be provided in a school-based health service environment. However, not all children respond to care, and school programs can result in under- or over-treatment, leaving children at high risk. The Building Adaptive School-based Interventions for Caries (BASICS) study will identify the optimal sequence and intensity of these treatments to minimize nonresponse, creating adaptive interventions tailored to specific needs in order to personalize school-based dental medicine.

Official title: The Building Adaptive School-based Interventions for Caries Study (BASICS): A Phase III Sequential, Multiple-Assignment, Randomized Trial of Minimally Invasive Therapies to Reduce Treatment Nonresponse

Key Details

Gender

All

Age Range

5 Years - 13 Years

Study Type

INTERVENTIONAL

Enrollment

1200

Start Date

2026-09

Completion Date

2030-06

Last Updated

2026-03-02

Healthy Volunteers

Yes

Conditions

Interventions

DEVICE

Silver Diamine Fluoride (38%)

Topically applied silver diamine fluoride 38% solution

DEVICE

Glass Ionomer Sealant

GIC Dental Sealants

DEVICE

Fluoride Varnishes

Topically applied fluoride varnish (FV)

BEHAVIORAL

Hygiene Intervention

Behavioral intervention to improve dental hygiene