Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
NOT YET RECRUITING
NCT07266025
PHASE2

Adebrelimab Combined With Induction Chemotherapy or SHR-8068 for Mismatch Repair-Deficient/Microsatellite Instability-High (dMMR/MSI-H) Locally Advanced Gastric/Gastroesophageal Junction Adenocarcinoma:A Randomized, Non-comparative Phase 2 Study

Sponsor: Shanghai Zhongshan Hospital

View on ClinicalTrials.gov

Summary

This is a randomized, non-comparative, open-label, two-arm phase II clinical trial designed to evaluate the efficacy and safety of neoadjuvant therapy with adebrelimab plus induction chemotherapy versus adebrelimab plus SHR-8086 in patients with dMMR/MSI-H gastric or gastroesophageal junction adenocarcinoma.

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2026-01-30

Completion Date

2030-06-30

Last Updated

2026-01-27

Healthy Volunteers

No

Interventions

DRUG

Adebrelimab

Participants in both arms will receive neoadjuvant adebrelimab 1200mg intravenously on day 1 of a 21-day cycle for four cycles.

DRUG

XELOX

Participants assigned to arm 1 will receive neoadjuvant XELOX (capecitabine 1000 mg/m² orally twice daily on days 1-14 plus oxaliplatin 130 mg/m² intravenously on day 1) for one cycle.

DRUG

SHR-8068

Participants assigned to arm 2 will receive SHR-8068 280 mg administered intravenously on day 1 for one cycle.

PROCEDURE

D2 radical gastrectomy

Curative-intent D2 radical gastrectomy is scheduled 4-6 weeks after completion of the fourth cycle.