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Toluidine Blue-Based Photodynamic Therapy for Antibacterial Activity and Postoperative Pain
Sponsor: Ataturk University
Summary
This clinical study aims to evaluate the antimicrobial effectiveness and postoperative pain outcomes of photodynamic therapy using Toluidine Blue O as an adjunct to conventional root canal treatment in patients diagnosed with symptomatic irreversible pulpitis. Photodynamic therapy is a non-invasive light-activated disinfection method, and this study will compare its performance with standard endodontic treatment protocols. The results are expected to provide clinical evidence regarding its potential benefits in reducing intracanal bacterial load and improving postoperative patient comfort.
Official title: Evaluation of the Antibacterial Activity and Postoperative Pain Outcomes of Photodynamic Therapy Using Toluidine Blue
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2025-06-01
Completion Date
2026-03
Last Updated
2025-12-05
Healthy Volunteers
No
Conditions
Interventions
Toluidine Blue O (0.1 mg/mL)
A 0.1 mg/mL toluidine blue O solution used as the photosensitizer for photodynamic therapy. The solution is placed into the root canal prior to 630-nm LED irradiation for activation.
630-nm LED Light Device
A light-emitting diode device delivering 630-nm wavelength used to activate toluidine blue O during photodynamic therapy. The device is positioned near the tooth for 60 seconds.
Photodynamic Therapy (PDT)
Application of 0.1 mg/mL toluidine blue O into the root canal, followed by activation with a 630-nm LED light source for 60 seconds as part of the experimental disinfection protocol.
Sham Photodynamic Therapy
Placebo photodynamic procedure in which the LED device is positioned similarly but activated without delivering light energy; no toluidine blue O is applied.
Locations (1)
Atatürk University, Faculty of Dentistry, Department of Endodontics
Erzurum, Turkey (Türkiye)