Inclusion Criteria:
* Able to read, understand, and willing to sign an informed consent form (ICF) and complete questionnaires written in English.
* Generally healthy males or females, 21 to 60 years of age, inclusive, at the time of consent.
* Smokes combustible, filtered, non-menthol (Arm 1 only) or menthol cigarettes (Arm 2 only), 83 mm to 100 mm in length as primary source of tobacco. Smokers who also use other tobacco products (e.g., ENDS, smokeless tobacco, HTPs) will not be excluded from study participation,
* Smokes an average of at least 10 cigarettes per day (CPD) and inhales the smoke, for at least 6 months prior to Screening. Brief periods of abstinence due to illness, quit attempt (prior to 30 days of Screening), or clinical study participation (prior to 30 days of Screening) will be allowed at the discretion of the PI.
* Agrees to smoke the same UB cigarette throughout the study period. The UB cigarette is defined as the reported cigarette brand and style currently smoked most frequently by the participant.
* Expired breath carbon monoxide (ECO) level is ≥ 10 ppm and ≤ 100 ppm at Screening and at check-in (Day -1).
* Positive urine cotinine test (e.g., \>200 ng/mL) via dipstick at Screening.
* Response at Screening to the Fagerström Test for Nicotine Dependence (FTND) Question 1 ("How soon after you wake up do you smoke your first cigarette?") is either "Within 5 minutes" or "6-30 minutes" (Heatherton et al., 1991).
* Willing to use the UB cigarette, Study IPs, and Nicorette® nicotine gum during the study period.
* Willing to abstain from tobacco and nicotine use for at least 12 hours prior to the start of each of four Test Sessions.
* Females must be willing to use a form of contraception acceptable to the PI from the time of signing the ICF until End-of-Study.
* Examples of acceptable means of birth control are, but not limited to:
* Surgical sterilization (hysterectomy, bilateral tubal ligation/occlusion, bilateral
* oophorectomy, bilateral salpingectomy);
* physical barrier method (e.g., condom, diaphragm/sponge/cervical cap) with
* spermicide;
* non-hormone releasing intrauterine devices (IUD) or hormone-releasing IUDs
* (e.g., Mirena or Kyleena);
* vasectomized partner; or
* post-menopausal and not on hormone replacement therapy
* abstinence.
* Males must use an acceptable method of birth control from Day -1 "check-in" until the End-of-Study, unless they have had a vasectomy or are abstinent from heterosexual intercourse, or their female partner is not able to bear children.
* Agrees to an in-clinic confinement of 10 days (9 nights).
* BMI within 18.0 to 40.0 kg/m2, inclusive (minimum weight of at least 50.0 kg at Screening).
Exclusion Criteria:
* Individuals or their family members that have ongoing litigation with tobacco company(ies).
* Presence of clinically significant uncontrolled cardiovascular, pulmonary, renal, hepatic, endocrine, gastrointestinal, psychiatric, hematological, neurological disease, or any other concurrent disease or medical condition that, in the opinion of the PI, makes the study participant unsuitable to participate in this clinical study.
* History, presence of, or clinical laboratory test results indicating diabetes.
* Scheduled treatment for asthma currently or within the past consecutive 12 months prior to the Screening Visit. As-needed treatment, such as inhalers, may be included at the PI's discretion.
* History or presence of bleeding or clotting disorders.
* Any history of cancer, except for primary cancers of skin such as localized basal cell/squamous cell carcinoma that has been surgically and/or cryogenically removed.
* Systolic BP of \> 160 mmHg or a diastolic BP of \> 95 mmHg, measured after being seated for 5 minutes at Screening or at check-in Day -1.
* Weight of \> 50.0 kg at Screening.
* Hemoglobin level is \> 12.5 g/dL for females or \> 13.0 g/dL for males at Screening.
* Females who have a positive pregnancy test, are pregnant, breastfeeding, or intend to become pregnant during the course of the study.
* Has positive urine drug screen or alcohol test (urine or breath) at Screening or at Check-in to the Assessment Phase (Day -1), with the exception of positive results for tetrahydrocannabinol (THC). If positive for THC at check-in (Day -1), a cannabis intoxication evaluation will be performed, and inclusion will be at the discretion of the PI.
* Positive test for human immunodeficiency virus (HIV), hepatitis B surface antigen (HbsAg), or hepatitis C virus (HCV).
* Use of any medication or substance that aids in smoking cessation, including but not limited to any NRT (e.g., nicotine gum, lozenge, patch), varenicline (Chantix®), bupropion (Wellbutrin®, Zyban®), GLP-1 agonists (e.g., Mounjaro®, Ozempic®, Wegovy®), or lobelia extract within (≤) 30 days prior to signing the informed consent.
* Postpones a decision to quit using tobacco- or nicotine-containing products in order to participate in this study or self-reports a previous quit attempt within (≤) 30 days prior to signing the informed consent.
* Any use of daily aspirin (≥ 325 mg) or any use of other anticoagulants.
* Individuals ≥ 35 years of age currently using systemic, testosterone, estrogen-containing contraception or hormone replacement therapy.
* Whole blood donation or lost blood or blood products in excess of 500 mL within 8 weeks (≤ 56 days) prior to signing the informed consent and between Screening and check-in Day -1.
* Plasma donation within (≤) 7 days prior to signing the informed consent and between Screening and check-in Day -1.
* Employed by a tobacco or nicotine company, the study site, or handles raw, unpackaged tobacco- or nicotine-containing products as part of their job.
* Has used an investigational drug, device, biologic, or tobacco/nicotine product in a previous clinical study within 30 days or 5 times the half-life of the product (whichever is longer) prior to Screening.
* Drinks more than 21 servings of alcoholic beverages per week.
* Determined by the PI to be inappropriate for this study.
