Clinical Research Directory

Inclusion Criteria: 1. Patients aged 19 years or older. 2. Patients who have maintained stable liver graft function for one year after liver transplantation due to HBV and meet the following conditions: 1. AST and ALT \< 35IU/L 2. HBsAg: Negative 3. HBV DNA: Not detected 3. Patients who have been taking entecavir for HBV prophylaxis for at least 1 year. 4. Patients with a tacrolimus trough level maintained between 3-10 ng/mL. 5 .Patients who have voluntarily decided to participate in the clinical trial after fully understanding the detailed explanation of the trial and have provided written consent. Exclusion Criteria: 1. Patients who have undergone transplantation of organs other than the liver or re-transplantation. 2. Patients who have received bioartificial liver system treatment or auxiliary partial orthotopic liver transplantation (APOLT) before the transplantation. 3. Patients with concurrent viral infections (HCV, HIV). 4. Patients with eGFR \<30 or those undergoing dialysis 5. Pregnant or breastfeeding women. 6. Patients or their spouses/partners who do not agree to use medically acceptable and appropriate contraception methods\* during the clinical trial period. \* Appropriate contraception methods: hormonal contraception, intrauterine device (IUC or IUS), tubal ligation, tubal occlusion, hysterectomy, vasectomy, double barrier methods (combined use of male or female condoms with cervical caps, diaphragms, or contraceptive sponges), single barrier methods with spermicide. 7. Patients with a history of hypersensitivity to Entecavir. 8. Patients who are deemed unsuitable for participation in the clinical trial by the investigator.