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Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
Sponsor: Loughborough University
Summary
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans. Antiresorptive medications are commonly prescribed to reduce bone resorption, preventing further bone loss and thus reducing the possibility of fracture. Exercise can also benefit bone mass and structure but current evidence do not show whether exercise is more, or less, effective in combination with antiresorptive medication. This study will compare the effect of a brief, home-based exercise programme on bone mineral and structural properties in women taking/ not taking antiresorptive medication.
Official title: The Effect of Exercise With or Without Antiresorptive Therapy, on Bone Properties in Postmenopausal Women With Low BMD - Randomised Controlled Unilateral Intervention Trial
Key Details
Gender
FEMALE
Age Range
55 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
110
Start Date
2026-01-01
Completion Date
2027-09
Last Updated
2025-12-05
Healthy Volunteers
Yes
Conditions
Interventions
EXERCISE TRAINING
The unilateral high-impact (hopping) exercise will be on one randomly allocated exercise leg, with the contralateral leg being untrained to provide a control leg. Each session will begin with a warm-up targeting the legs and lower back. The progressive exercise regimen consists of multidirectional hopping exercises that will gradually increase in technique, intensity, and frequency to ensure safety. It will be personalised according to the participants' physical abilities and responses during or after the exercise.
Antiresorptive medication (routine clinical care)
Participants in this arm are already taking prescribed antiresorptive medication as part of standard clinical care. The study will not provide or modify the medication.
Locations (1)
Loughborough University
Loughborough, Leicestershire, United Kingdom