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NOT YET RECRUITING
NCT07268690
PHASE3

Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma

Sponsor: Fujian Cancer Hospital

View on ClinicalTrials.gov

Summary

This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study will evaluate whether omitting Level Va irradiation in patients without these risk features does not compromise regional control or survival, with the goal of providing robust evidence to guide further personalization of NPC radiotherapy.

Official title: Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma: A Phase III Randomized Non-Inferiority Trial

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

474

Start Date

2026-01-01

Completion Date

2030-12-31

Last Updated

2025-12-08

Healthy Volunteers

No

Interventions

RADIATION

Omission of Level Va Irradiation in Nasopharyngeal Carcinoma

Level Va should be irradiated only in the presence of any of the following high-risk features: 1. Ipsilateral Level IIb involvement; 2. Ipsilateral Level III nodes involvement; 3. Ipsilateral positive lymph nodes below the cricoid cartilage (Level IV or Vb-c).

Locations (1)

Fujian Cancer hospital

Fuzhou, Fujian, China