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Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma
Sponsor: Fujian Cancer Hospital
Summary
This is a randomized, phase III, prospective, multi-center trial in newly diagnosed nasopharyngeal carcinoma (NPC) patients without distant metastasis. This study will evaluate whether omitting Level Va irradiation in patients without these risk features does not compromise regional control or survival, with the goal of providing robust evidence to guide further personalization of NPC radiotherapy.
Official title: Risk-Adapted Omission of Level Va Irradiation in Nasopharyngeal Carcinoma: A Phase III Randomized Non-Inferiority Trial
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
474
Start Date
2026-01-01
Completion Date
2030-12-31
Last Updated
2025-12-08
Healthy Volunteers
No
Interventions
Omission of Level Va Irradiation in Nasopharyngeal Carcinoma
Level Va should be irradiated only in the presence of any of the following high-risk features: 1. Ipsilateral Level IIb involvement; 2. Ipsilateral Level III nodes involvement; 3. Ipsilateral positive lymph nodes below the cricoid cartilage (Level IV or Vb-c).
Locations (1)
Fujian Cancer hospital
Fuzhou, Fujian, China