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Heartburn, Gastroesophageal Reflux Disease
Sponsor: Incheon St.Mary's Hospital
Summary
Gastroesophageal reflux disease (GERD) is a condition caused by the reflux of stomach contents into the esophagus, presenting with typical symptoms such as heartburn and acid regurgitation. GERD is a chronic condition that affects quality of life, and patients with this condition are known to have a lower quality of life compared to healthy individuals. In particular, nocturnal heartburn can lead to sleep deprivation and affect daily life, as well as overall quality of life. This study aims to evaluate the efficacy of alleviating nocturnal heartburn symptoms in patients with erosive reflux disease (ERD).
Official title: A Multicenter, Double-blind, Randomized, Investigator-initiated Trial to Evaluate the Degree of Symptom Relief of Zastaprazan and Esomeprazole in Patients With Erosive Reflux Disease With Night-time Heartburn Symptoms
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
160
Start Date
2025-07-07
Completion Date
2026-09-30
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
Zastaprazan
Participants in this arm will receive zastaprazan. This group serves as the experimental treatment group exploratorily evaluating drug for GERD.
Esomeprazole
Participants in this arm will receive esomeprazole. This group serves as the active comparator treatment group exploratorily evaluating drug for GERD.
Locations (10)
Korea University Ansan Hospital
Ansan, South Korea
Pusan National University Hospital
Busan, South Korea
Kyungpook National University Chilgok Hospital
Chilgok, South Korea
Hallym University Chuncheon Sacred Heart Hospital
Chuncheon, South Korea
Chonnam National University Hospital
Gwangju, South Korea
Catholic University of Korea, Incheon ST. Mary's Hospital
Incheon, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Kyung Hee University Hospital
Seoul, South Korea
Soonchunhyang University Hospital
Seoul, South Korea
Pusan National University Yangsan Hospital
Yangsan, South Korea