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RECRUITING
NCT07269093
NA

Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil

Sponsor: Universiti Sains Malaysia

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

120

Start Date

2025-12-21

Completion Date

2026-11

Last Updated

2026-01-02

Healthy Volunteers

No

Interventions

DEVICE

Chitosan cream

Application of Chitosan cream twice daily for 8 weeks

DEVICE

Silicone Gel

Application of silicone gel twice a day for 8 weeks

DEVICE

Olive Oil Topical Oil

Application of olive oil twice daily for 8 weeks

Locations (3)

Hospital Raja Perempuan Zainab II

Kota Bharu, Kelantan, Malaysia

Hospital Pakar Universiti Sains Malaysia

Kubang Kerian, Kelantan, Malaysia

Hospital Kuala Lumpur

Kuala Lumpur, Kuala Lumpur, Malaysia