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Efficacy in Preventing Hypertrophic Scars: A Randomised Controlled Trial Comparing Chitosan Cream, Silicone Gel & Olive Oil
Sponsor: Universiti Sains Malaysia
Summary
The goal of this clinical trial is to compare the efficacy of three different topical applications in preventing hypertrophic scars in adults with scars healed after suturing. The main question it aims to answer is: Is Chitosan cream effective in preventing hypertrophic scars? Researchers will compare Chitosan cream with silicone gel and olive oil to see if there is any difference in their efficacies. Participants will be randomly assigned to three groups, with each group using a different topical application. They will be instructed to: * apply the topical application on their scar twice a day for 8 weeks * attend follow-up visits at 4, 12 and 24 weeks for a doctor to assess their scar and take clinical photographs * immediately inform the researcher if they experience any side effects
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-12-21
Completion Date
2026-11
Last Updated
2026-01-02
Healthy Volunteers
No
Conditions
Interventions
Chitosan cream
Application of Chitosan cream twice daily for 8 weeks
Silicone Gel
Application of silicone gel twice a day for 8 weeks
Olive Oil Topical Oil
Application of olive oil twice daily for 8 weeks
Locations (3)
Hospital Raja Perempuan Zainab II
Kota Bharu, Kelantan, Malaysia
Hospital Pakar Universiti Sains Malaysia
Kubang Kerian, Kelantan, Malaysia
Hospital Kuala Lumpur
Kuala Lumpur, Kuala Lumpur, Malaysia