Clinical Research Directory

Inclusion Criteria: * Age 18 or older that meet diagnostic criteria for CRS with or without polyposis as documented by their recruiting physician. * Diagnostic criteria for CRS will be defined according to EPOS criteria of \>12 weeks of 2 of the following subjective symptoms: nasal blockage or obstruction, rhinorrhea, hyposmia, or facial pain/pressure AND objective evidence of CRS on either nasal endoscopy or CT scan Exclusion Criteria: * Patients who have previously undergone sinus surgery * Severe polyposis; defined as Lund Kennedy endoscopy score greater than 1 * Patients who are currently using or who have previously used biologic medications for their nasal polyps. These medications include: dupilumab, omalizumab, mepolizumab, tezepelumab, or depemokimab * Inability to complete surveys in English * known comorbid mucociliary disease * known adrenal disease or other HPA dysfunction * patients taking oral corticosteroids for other medical conditions * oral antibiotic administration within 2 weeks of study participation * a baseline SNOT-22 score less than 9, due to inability to achieve the MCID