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NOT YET RECRUITING
NCT07270848
PHASE4

Dronedarone Rhythm Intervention for Early Atrial Fibrillation

Sponsor: Inha University Hospital

View on ClinicalTrials.gov

Summary

The purpose of this study is to compare two commonly used types of medicine for treating atrial fibrillation (also called AF), a condition that causes an irregular heart rhythm. This study is for adults who have been diagnosed with AF within the past year. Researchers want to find out which medicine is more effective, safer, and provides a better quality of life for patients needing to control their heart rhythm. Participants who agree to join the study will be randomly assigned (like flipping a coin) to one of two groups: Group 1: Will receive the medicine Dronedarone. Group 2: Will receive a standard medicine from the 'Class Ic' group (such as flecainide or propafenone). The study will follow participants for at least 12 months. Researchers will compare how well each medicine works to prevent AF from coming back. They will also carefully track any side effects and changes in participants' quality of life during the study.

Official title: A Multicenter Prospective Study on the Efficacy, Safety, and Quality of Life Improvements of Dronedarone for Early Rhythm Control in Atrial Fibrillation

Key Details

Gender

All

Age Range

19 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1898

Start Date

2026-01-01

Completion Date

2028-12

Last Updated

2025-12-22

Healthy Volunteers

No

Interventions

DRUG

Dronedarone

Dronedarone 400 mg administered orally twice daily.

DRUG

flecainide

Administered orally according to standard clinical practice.

DRUG

propafenone

Administered orally according to standard clinical practice.

Locations (16)

Inha University Hospital

Incheon, Incheon, South Korea

Korea University Ansan Hospital

Ansan, South Korea

Soonchunhyang University Bucheon Hospital

Bucheon-si, South Korea

Kosin University Gospel Hospital

Busan, South Korea

Soonchunhyang University Cheonan Hospital

Cheonan, South Korea

Inje University Ilsan Paik Hospital

Goyang, South Korea

NHIS Ilsan Hospital

Goyang-si, South Korea

Myongji Hospital

Goyang-si, South Korea

Hanyang University Guri Hospital

Guri-si, South Korea

Jeju National University Hospital

Jeju City, South Korea

Sejong Chungnam National University Hospital

Sejong, South Korea

Korea University Anam Hospital

Seoul, South Korea

Severance Hospital

Seoul, South Korea

Ewha Womans University Seoul Hospital

Seoul, South Korea

Korea University Guro Hospital

Seoul, South Korea

Wonju Severance Christian Hospital

Wŏnju, South Korea