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Dronedarone Rhythm Intervention for Early Atrial Fibrillation
Sponsor: Inha University Hospital
Summary
The purpose of this study is to compare two commonly used types of medicine for treating atrial fibrillation (also called AF), a condition that causes an irregular heart rhythm. This study is for adults who have been diagnosed with AF within the past year. Researchers want to find out which medicine is more effective, safer, and provides a better quality of life for patients needing to control their heart rhythm. Participants who agree to join the study will be randomly assigned (like flipping a coin) to one of two groups: Group 1: Will receive the medicine Dronedarone. Group 2: Will receive a standard medicine from the 'Class Ic' group (such as flecainide or propafenone). The study will follow participants for at least 12 months. Researchers will compare how well each medicine works to prevent AF from coming back. They will also carefully track any side effects and changes in participants' quality of life during the study.
Official title: A Multicenter Prospective Study on the Efficacy, Safety, and Quality of Life Improvements of Dronedarone for Early Rhythm Control in Atrial Fibrillation
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1898
Start Date
2026-01-01
Completion Date
2028-12
Last Updated
2025-12-22
Healthy Volunteers
No
Conditions
Interventions
Dronedarone
Dronedarone 400 mg administered orally twice daily.
flecainide
Administered orally according to standard clinical practice.
propafenone
Administered orally according to standard clinical practice.
Locations (16)
Inha University Hospital
Incheon, Incheon, South Korea
Korea University Ansan Hospital
Ansan, South Korea
Soonchunhyang University Bucheon Hospital
Bucheon-si, South Korea
Kosin University Gospel Hospital
Busan, South Korea
Soonchunhyang University Cheonan Hospital
Cheonan, South Korea
Inje University Ilsan Paik Hospital
Goyang, South Korea
NHIS Ilsan Hospital
Goyang-si, South Korea
Myongji Hospital
Goyang-si, South Korea
Hanyang University Guri Hospital
Guri-si, South Korea
Jeju National University Hospital
Jeju City, South Korea
Sejong Chungnam National University Hospital
Sejong, South Korea
Korea University Anam Hospital
Seoul, South Korea
Severance Hospital
Seoul, South Korea
Ewha Womans University Seoul Hospital
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
Wonju Severance Christian Hospital
Wŏnju, South Korea