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Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
Sponsor: Regeneron Pharmaceuticals
Summary
This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times
Official title: A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ANGPTL3 Inhibition With Either Small-Interfering RNA Alone or in Combination With an ANGPTL3 Antibody in Participants With Diabetic Kidney Disease
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
270
Start Date
2026-01-09
Completion Date
2028-04-07
Last Updated
2026-03-17
Healthy Volunteers
No
Conditions
Interventions
ALN-ANG3
Administered per the protocol
Evinacumab
Administered per the protocol
ALN-ANG3 placebo
Administered per the protocol
Evinacumab placebo
Administered per the protocol
Locations (29)
Applied Research Center of Arkansas
Little Rock, Arkansas, United States
Amicis Research Center
Northridge, California, United States
Central Coast Nephrology
Salinas, California, United States
North America Research Institute
San Dimas, California, United States
Amicis Research Center
Santa Clarita, California, United States
Amicis Research Center
Valencia, California, United States
D&H Doral Research Center
Doral, Florida, United States
AGA Clinical Trials
Hialeah, Florida, United States
Convenient Medical Center
Hialeah, Florida, United States
Elixia Hollywood
Hollywood, Florida, United States
D&H Pompano Research Center
Margate, Florida, United States
LCC Medical Research Institute
Miami, Florida, United States
D&H National Research Centers, Inc
Miami, Florida, United States
Regenerate Primary Medical Research, LLC
Miami, Florida, United States
Ocean Blue Medical Research Center - Internal Medicine
Miami Springs, Florida, United States
Innovia Research Center
Miramar, Florida, United States
Bolanos Clinical Research
Pembroke Pines, Florida, United States
D&H Tamarac Research Center
Tamarac, Florida, United States
Metabolic Research Institute
West Palm Beach, Florida, United States
Research by Design, LLC - Internal Medicine
Chicago, Illinois, United States
Elixia Michigan Kidney Consultants
Pontiac, Michigan, United States
Elixia MNA
City of Saint Peters, Missouri, United States
Clinical Research Consultants, LLC
Kansas City, Missouri, United States
Brookview Hills Research Associates, LLC
Winston-Salem, North Carolina, United States
Northeast Clinical Research Center
Bethlehem, Pennsylvania, United States
Suburban Research Associates
West Chester, Pennsylvania, United States
Southeast Renal Research Institute
Chattanooga, Tennessee, United States
Arlington Nephrology, PLLC.
Arlington, Texas, United States
Clinical Trial Network, LLC
Houston, Texas, United States