Clinical Research Directory

Inclusion criteria common to both experimental groups: * Signature of informed consent * Age between 55 and 80 years * Absence of functional impact on daily living activities or minimal impact on instrumental activities Specfic inclusion criteria for Healthy Controls recruitment: * Normal global cognitive efficiency (Mini Mental State Examination scores of 28 or higher) * Absence of specific cognitive deficits (memory and other cognitive domains) that are abnormal for age, sex, and education level (1.5 standard deviations below the mean for age- and education-matched controls), as assessed by objective, standardized cognitive tests. Specific inclusion criteria for aMCI recruitment: * Cognitive difficulties reported by the individual, their family member, or their primary care physician * Normal global cognitive efficiency (Mini Mental State Examination score within 0.5 standard deviations of the average for age- and education-matched control subjects). * Specific cognitive deficits related to memory or multi-domain cognitive impairments (involving memory and other cognitive domains) that are atypical for the individual's age (1.5 standard deviations below the average for age- and education-matched controls), as determined by objective, standardized cognitive tests. Exclusion Criteria: * Rejection of informed consent * Important sensory deficits (e.g., hearing loss or hypovisus) * Current or previous history of psychiatric illness * Current or previous degenerative pathology of the central nervous system (CNS) * Presence of systemic diseases in anamnesis * Presence of cerebrovascular events in anamnesis * Use of alcohol or psychotropic substances in anamnesis