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Remote Ischemic Postconditioning in Septic Shock
Sponsor: Hospices Civils de Lyon
Summary
Septic shock is a leading cause of death worldwide despite intensive research efforts. Only a few interventions have been proven to be effective in improving patient-centered outcomes. Recent clinical trials have reported the safety and efficacy of remote ischemic postconditioning (RIPOST) in a variety of pathologies, including myocardial infarction, cardiac surgery, and stroke. While RIPOST was mainly tested in pathologies with low mortality rates, several follow-up studies of large randomized clinical trials in acute myocardial infarction and in patients undergoing coronary artery bypass surgery have reported significant decreases (\> 50%) in long-term mortality. Experimental studies and proof-of-concept clinical trials have also suggested the potential benefits of RIPOST on mortality in sepsis and septic shock. The present protocol aims to test whether this non-invasive, widely available, inexpensive, and innovative intervention can improve survival in septic shock.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
720
Start Date
2026-04
Completion Date
2028-07
Last Updated
2026-01-28
Healthy Volunteers
No
Interventions
Remote ischemic conditioning
A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of alternating inflations and deflations of the brachial cuff. Four cycles of ischemic conditioning (5-min brachial cuff inflation at 200 mmHg followed by 5-min cuff deflation) are started as soon as possible after inclusion. The intervention is repeated 12 and 24 hours after inclusion.
No intervention
No intervention will be performed in the conrol group
Locations (23)
Service de Réanimation Médicale, Hôpital Jean-Minjoz, CHU de Besançon
Besançon, France
Service Réanimation Polyvalente, Centre Hospitalier de Fleyriat
Bourg-en-Bresse, France
Service de Médecine Intensive- Réanimation, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand
Clermont-Ferrand, France
Service de Médecine Intensive-Réanimation, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris
Créteil, France
Service de Médecine intensive-Réanimation,Hôpital F Mitterrand, CHU de Dijon
Dijon, France
Service de Médecine intensive-Réanimation,Hôpital Albert Michallon, CHU de Grenoble
La Tronche, France
Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, Assistance Publique des Hôpitaux de Paris
Le Kremlin-Bicêtre, France
Service de Médecine Intensive-Réanimation, Hôpital Salengro, CHU de Lille
Lille, France
Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon
Lyon, France
Service Réanimation Polyvalente, Hôpital Saint-Joseph Saint-Luc
Lyon, France
Service de Médecine Intensive-Réanimation, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille
Marseille, France
Service de Réanimation des Urgences, Hôpital de la Timone, CHU de Marseille
Marseille, France
Service de Médecine intensive-Réanimation, Hôpital Lapeyronie, CHU de Montpellier
Montpellier, France
Service de Médecine Intensive-Réanimation, Hôpital Central, CHRU de Nancy
Nancy, France
Service de Médecine Intensive-Réanimation, Hôtel Dieu, CHU de Nantes
Nantes, France
Service de Médecine Intensive - Réanimation, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris
Paris, France
Service d'Anesthésie - Réanimation - Médecine Intensive, Hôpital Lyon Sud, Hospices Civils de Lyon
Pierre-Bénite, France
Service de Médecine Intensive et Réanimation Polyvalente, Hôpital Robert Debré, CHU Reims
Reims, France
Service des maladies infectieuses et réanimation médicale, Hôpital Pontchaillou, CHU de Rennes
Rennes, France
Service Réanimation Polyvalente, Centre Hospitalier de Roanne
Roanne, France
Service de Médecine intensive-Réanimation, Hôpital Nord, CHU de St Etienne
Saint-Priest-en-Jarez, France
Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, CHU de Strasbourg
Strasbourg, France
Service de Médecine Intensive-Réanimation, Hôpital Bretonneau, CHRU de Tours
Tours, France