Clinical Research Directory

Inclusion Criteria: * Clinical diagnosis of primary trigeminal neuralgia according to the International Classification of Headache Disorders, 3rd edition (ICHD-3) * Age between 18 and 75 years * Severe trigeminal neuralgia not adequately relieved by conservative medical therapy, including carbamazepine or oxcarbazepine * Numeric Rating Scale (NRS-11) pain score of 7 or higher prior to the procedure * Ability and willingness to provide written informed consent Exclusion Criteria: * Secondary trigeminal neuralgia, including trigeminal neuralgia attributed to space-occupying lesions or multiple sclerosis * Infection at the puncture site * History of psychiatric disease * Clinically significant abnormalities in routine laboratory tests, including hepatic, renal, or coagulation function, or abnormalities on electrocardiogram or chest X-ray * Serious systemic diseases, including uncontrolled hypertension or diabetes mellitus, or cardiac dysfunction classified as New York Heart Association class II-III * History of narcotic substance abuse * Previous treatment with continuous radiofrequency to the gasserian ganglion or peripheral branches, glycerol rhizolysis, balloon compression, gamma knife surgery, or other neuroablative procedures * Previous microvascular decompression