Clinical Research Directory

Inclusion Criteria: * Aged between 12 and 75 years; * Diagnosed with moderate-to-severe atopic dermatitis (AD) ; * Participants (and legal representatives for adolescents) able to understand and communicate with the investigator. Exclusion Criteria: * Subject has any of the following abnormalities in clinical laboratory tests at screening, as assessed by the study-specific laboratory and confirmed by a single repeat, if deemed necessary: 1. Absolute lymphocyte count of \<0.50 x 10\^9 /L (\<500/mm3); 2. Absolute Neutrophil Count (ANC) of \<1 X 10\^9/L (\<1000/mm3); 3. Hemoglobin level \< 80 g/L. * Subject has any malignancies or has a history of malignancies with the exception of adequately treated or excised non-metastatic basal cell or squamous cell cancer of the skin, or cervical carcinoma in situ. * Subject with a prior history of thromboembolic events, including deep vein thromboses (DVT), pulmonary embolism, cerebrovascular accidents and those with known inherited conditions that predispose to hypercoagulability. * Presence of an active severe acute or chronic bacterial, fungal, or viral infection requiring systemic therapy. * Subjects with active tuberculosis or known active hepatitis B and/or hepatitis C infection. * Subjects with clinically significant diseases of the heart, liver, kidney, or other major organ systems. * Female subject who is pregnant, breastfeeding, or considering pregnancy during the study.