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Promoting Recovery After Brain Injury Using Focused Ultrasound
Sponsor: Massachusetts General Hospital
Summary
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
Key Details
Gender
All
Age Range
18 Years - 79 Years
Study Type
INTERVENTIONAL
Enrollment
36
Start Date
2026-03
Completion Date
2029-07
Last Updated
2026-02-18
Healthy Volunteers
No
Interventions
Low-intensity focused ultrasound
Low-intensity focused ultrasound pulsations (LIFUP) will be delivered to the brain, along with advanced MRI and EEG. Surrogate decision makers (family members) and recovered patients will undergo a semi-structured interview.
Locations (2)
Massachusetts General Hospital (The General Hospital Corp.)
Boston, Massachusetts, United States
Spaulding Rehabilitation Hospital Corporation, Inc.
Cambridge, Massachusetts, United States