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RECRUITING
NCT07278505
PHASE1/PHASE2

Study of Cannabidiol and Neuroimaging on Stress

Sponsor: Icahn School of Medicine at Mount Sinai

View on ClinicalTrials.gov

Summary

Dysregulation in stress responsivity is a growing psychiatry-transdiagnostic fundamental phenomenon, with limited therapeutic strategies. With the legalization of medical and recreational cannabis, many people consume cannabidiol (CBD; a nonintoxicating cannabinoid) to alleviate stress response, without the benefit of scientific guidance. To address this gap, the investigators propose a rigorous translational neuroscience study in a clinical high-risk population to define the roles of CBD in stress response with mechanisms of mesocorticolimbic-network function and hierarchy, neurometabolic, endocrine, and behavior, building upon convergent evidence from animal models and human evidence from our laboratories.

Official title: Pathophysiological Mechanisms of Cannabidiol in Stress Regulation

Key Details

Gender

All

Age Range

18 Years - 25 Years

Study Type

INTERVENTIONAL

Enrollment

160

Start Date

2025-10-28

Completion Date

2030-02-28

Last Updated

2025-12-12

Healthy Volunteers

Yes

Interventions

DRUG

Cannabidiol

400mg cannabidiol

DRUG

Placebo

Inactive oral solution

Locations (1)

Ichan School of Medicine at Mount Sinai

New York, New York, United States