Inclusion Criteria:
* English fluency
* 18 to 65 years of age.
* Diagnosed with MDD or MDE (Includes Remission, HAM-D \<= 7)
* Starting, or has started, a new treatment for depression or anxiety within 2-3 weeks of enrollment
* Access to a laptop or other computer with a well functioning microphone and webcam, and a stable Internet connection
* Stated willingness to comply with all study procedures and availability for the duration of the study
* Resides in the United States at the time of consent and during completion of study
Exclusion Criteria:
* Any cognitive impairment that limits ability to provide informed consent or authorization
* Vulnerable or protected populations (e.g. prisoners)
* Impairment that would prevent participants from completing an online survey and/or engaging in clinician assessment interviews (e.g., visual impairment, motor impairment, hearing impairment)
* Acute intoxication at the time of the assessments
* Concurrent medication/treatment:
* Receiving any fast-acting treatment for depression or anxiety (e.g. ketamine, psychedelics, deep brain stimulation, etc.) in between initial baseline assessment (A1) and Restest (A2) , or in between Follow up assessment (B1) and Retest (B2)
* Anxiolytics: Use of benzodiazepines or other anxiety-reducing medications that could affect speech or motor activity, within the past 4 weeks.
* Antipsychotics and Mood Stabilizers: Medications that can alter cognitive and motor functions, within the past 6 weeks.
* Stimulants: Use of medications like methylphenidate or amphetamines that affect energy levels and behavior, within the past 2 weeks
* Epilepsy medication: seizure activity or medication side effects that may alter behavior, within the past 4 weeks.
* Any history or evidence of any of the following conditions:
* Neurodevelopmental, Neurocognitive, Neurodegenerative or movement disorders including, but not limited to:
* Tourette's syndrome
* Multiple Sclerosis
* Amyotrophic Lateral Sclerosis
* Parkinson's Disease
* Stroke
* Traumatic Brain Injury
* Facial paralysis.
* Conditions with vocal cord impact:
* Vocal cord injury or cerebrovascular accident or head trauma with residual dysarthria in the past year
* Disorders that may impact vocal cords such as acute or chronic laryngitis, vocal cord paresis or paralysis, or spasmodic dysphonia
* Past or active heavy smokers (an average of \>20 cigarettes per day)
* Schizophrenia Spectrum and Other Psychotic Disorders:
* Individuals with a current or past diagnosis of Schizophrenia, Schizoaffective Disorder, or other psychotic disorders, including Delusional Disorder and Brief Psychotic Disorder.
* Current hypomanic episode as defined by DSM-5 criteria. This includes those with Bipolar I Disorder, Bipolar II Disorder, or Cyclothymic Disorder who are not in a stable mood state at the time of assessment.
* Chronic Pain Conditions: Such as fibromyalgia, which may affect facial expressions and vocal tone.
* Prosthetic Facial Devices: Could affect facial recognition algorithms. Cosmetic Procedures: Such as Botox injections or facelifts that can impact facial expressions.
* Dental Work: Major procedures that might affect speech.
* Participants who have previously participated in another research project by Deliberate.
