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TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%
Sponsor: Antalya Training and Research Hospital
Summary
This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.
Official title: TRIMPACT: A Prospective Real-World Study of Atezolizumab Monotherapy as First-Line (Stage IV) Treatment in Patients With Non-Small Cell Lung Cancer With PD-L1 Tumor Cell Expression ≥50% and No Targetable Mutations
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
150
Start Date
2025-09-15
Completion Date
2027-10-01
Last Updated
2025-12-12
Healthy Volunteers
No
Locations (19)
Afyonkarahisar Health Sciences University Hospital
Afyonkarahisar, Turkey (Türkiye)
Ankara Oncology Training and Research Hospital
Ankara, Turkey (Türkiye)
Memorial Ankara Hospital
Ankara, Turkey (Türkiye)
Ankara Bilkent City Hospital
Ankara, Turkey (Türkiye)
Antalya Training and Research Hospital
Antalya, Turkey (Türkiye)
Adnan Menderes University Faculty of Medicine Hospital
Aydin, Turkey (Türkiye)
Dicle University Hospital
Diyarbakır, Turkey (Türkiye)
Trakya University Faculty of Medicine Hospital
Edirne, Turkey (Türkiye)
Bahçelievler Memorial Hospital
Istanbul, Turkey (Türkiye)
İstanbul Medipol Mega Hospital
Istanbul, Turkey (Türkiye)
Ümraniye Training and Research Hospital
Istanbul, Turkey (Türkiye)
Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi
Istanbul, Turkey (Türkiye)
Dokuz Eylul University Faculty of Medicine Hospital
Izmir, Turkey (Türkiye)
Necmettin Erbakan University Meram Faculty of Medicine Hospital
Konya, Turkey (Türkiye)
Mersin University Faculty of Medicine Hospital
Mersin, Turkey (Türkiye)
Ordu State Hospital
Ordu, Turkey (Türkiye)
Sakarya University Faculty of Medicine Hospital
Sakarya, Turkey (Türkiye)
Medical Park Samsun Hospital
Samsun, Turkey (Türkiye)
Karadeniz Technical University Farabi Hospital
Trabzon, Turkey (Türkiye)