Clinical Research Directory

Inclusion Criteria: In order, to be eligible for the study, patients must fulfill all the following inclusion criteria: * Age between ≥50 and ≤80 years. * Be a current smoker or have quit 15 years ago or less. * Have participated or are currently participating in smoking cessation program. * Lifetime smoking exposure equal to or greater than 20 pack-year. * Provided signed informed consent (ICF) Exclusion Criteria: * In order, to be exclude for the study, patients must at least one of the following exclusion criteria: * Contraindications to the screening examination: (claustrophobic or weighing more than 130 kgs). * Inability to climb 3 stair steps non-stop (36 steps). * Disabling dyspnea * Symptomatic (with signs and symptoms suspicious of breast cancer lung, namely): * pleuritic chest pain * rapidly progressive dyspnea of recent onset * hemoptysis * unexplained hoarseness, lasting more than 1 month. * bone pain * supraclavicular lymphadenopathy or cervical lymphadenopathy persistent * unexplained weight loss of 5% or more of weight in less than 6 months * Previous history of malignant neoplasm (excluding non-melanoma skin cancer) diagnosed less than 10 years before the date of the interview; * Patients with diagnostic of severe psychiatric disease * Immunosuppressed by illness or drugs. * Subjected to anterior lung resection even when determined due to an etiology other than malignant neoplasia. * Person with a serious terminal illness that contraindicates curative lung surgery.