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Study of Skin and Gut Microbiome in a Skin Condition Involving Skin Barrier Impairment and Allergic Symptoms: Netherton Syndrome
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
It is proposed to conduct an exploratory study to analyze the skin, intestinal, and salivary microbiome, as well as the skin mycobiome and virome, of patients (adolescents and young adults) with Netherton syndrome, a condition characterized by an impaired skin barrier that most likely promotes the development of allergic manifestations. The study will be conducted on patients with Netherton syndrome and control subjects in order to investigate possible correlation factors between the three microbiomes and identify which ones.
Key Details
Gender
All
Age Range
10 Years - Any
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2025-12
Completion Date
2027-12
Last Updated
2025-12-23
Healthy Volunteers
No
Conditions
Interventions
Superficial skin swabs
Sampling areas: (18 swabs in total + 6 swabs for routine skin mapping) 1. Lesion area outside skin folds (e.g., back or limb) 2. Healthy area outside skin folds (e.g., back or limb) 3. Perioral area of the face 4. Scalp 5. Inguinal fold 6. Axillary fold
Superficial skin swabs
Three superficial skin swabs: same locations as for Netherton patients
Stool samples
A stool sample collected for analysis of the fecal microbiome and mycobiome.
Saliva samples
A saliva sample collected for analysis of the saliva microbiome and mycobiome.
Blood samples
For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment
Blood samples
For group A: cytokine profile from an additional blood sample taken during a blood draw for treatment For group B: cytokine profile if there is any residual blood sample from the treatment
Data-Collection
Socio-demographic data and lifestyle habits of the patient and parents
Data-Collection
Clinical data, treatment data, and results of biological tests carried out as part of routine monitoring
Locations (1)
Hôpital Necker Enfants Malades
Paris, Île-de-France Region, France