Clinical Research Directory

Epigenetic Profiling and Liquid Biopsy: Perspectives for Personalized Medicine in Meningioma Patients - MIND

Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta

Summary

Meningiomas are the most common primary intracranial tumors. Current treatment relies on surgical resection and radiotherapy, but molecular predictors for recurrence are lacking. This study aims to investigate epigenetic features, specifically histone post-translational modifications (PTMs) and DNA methylation, to stratify patients. The study involves a retrospective cohort to define an epigenetic signature and a prospective cohort to validate it in tissues and liquid biopsies (plasma/EVs).

Official title: Epigenetic Profiling and Liquid Biopsy: Perspectives for Personalized Medicine in Meningioma Patients

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