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Effects of Single-Dose Nicotinamide Riboside (NR) on Sleep
Sponsor: Eye & ENT Hospital of Fudan University
Summary
This study aims to evaluate whether a single oral dose of nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has acute effects on sleep in healthy adults who report mild sleep difficulties. NR is widely used as a nutritional supplement and is known to increase cellular NAD+ levels, which may influence physiological processes linked to sleep-wake regulation. In this randomized, double-blind, placebo-controlled study, 28 healthy adults will complete two overnight sleep assessments using polysomnography (PSG), the gold-standard sleep monitoring method. After a baseline night of sleep recording, participants will receive either NR or a placebo before bedtime on the second night. The primary outcome is the change in N3 sleep duration from the baseline night to the intervention night. Subjective sleep quality assessed using the Leeds Sleep Evaluation Questionnaire (LSEQ), together with other objective sleep measures derived from PSG, will be evaluated as secondary outcomes.
Official title: Efficacy of a Single Dose of Nicotinamide Riboside (NR) on Sleep: A Randomized Controlled Study
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
28
Start Date
2025-12-17
Completion Date
2026-09-01
Last Updated
2026-09-16
Healthy Volunteers
Yes
Conditions
Interventions
Nicotinamide Riboside (NR)
A single oral dose of 600 mg NR, an NAD+ precursor compound, provided in capsule form. The dose and timing are standardized for all participants.
Placebo
The placebo capsule is visually identical to the NR capsule but contains inert excipients without active pharmacological components.
Locations (1)
Eye & ENT Hospital of Fudan University
Shanghai, Shanghai Municipality, China