Clinical Research Directory

Inclusion Criteria: 1. adults aged 50 and above; 2. living in community for at least one year and having established medical records; 3. denying a history of cognitive disorders (mild cognitive impairment, dementia, Alzheimer's disease, etc.) and the use of anti-dementia drugs (cholinesterase inhibitors or memantine, etc.); 4. agreeing to participate in the study; 5. individual or their relatives can communicate normally in Chinese. 6. high-risk groups for dementia（including:1. Complaints of cognitive decline and/or statements by the informant;2. History of AD in first-degree relatives;3. Known ApoE e4 carrier.） Exclusion Criteria: 1. Self-reporting or confirmation through inquiry indicates the presence of severe mental disorders, such as bipolar disorder or schizophrenia, etc. 2. Having a disease that makes it impossible to complete the cognitive assessment.