Clinical Research Directory

Inclusion Criteria: * Children diagnosed with Down syndrome (Non disjunction Trisomy 21) based on genetic testing . * Age between 4-8 years old . * Down syndrome children presented with difficulties in attention or focus as reported by parents or based on prior clinical assessments. Exclusion Criteria: * Parents' refusal. * Down syndrome children with other significant developmental or neurological disorders (e.g., autism spectrum disorder, epilepsy). * Patients with any chronic illness as liver or renal dysfunction; inflammatory diseases; autoimmune disease; cancer, acute cardiovascular event, eating disorders (anorexia, bulimia) or gastrointestinal disorders. * Presence of hypersensitivity to spearmint or any components of Neumentix (Neumentix may increase kidney or liver damage if used in large amounts). * Use of stimulant ADHD medication or cognitive-enhancing supplements . * IQ test less than 55%. * Patients with hypothyroidism.