Clinical Research Directory
Browse clinical research sites, groups, and studies.
MRgFUS for Parkinson's Tremor
Sponsor: Aarhus University Hospital
Summary
This study investigates magnetic resonance-guided focused ultrasound thalamotomy (MRgFUSth) for people with Parkinson's disease (PD) and tremor not responding to conventional standard doses of dopamine replacement therapy. The aim is to identify clinical and imaging biomarkers predictive of sustained tremor control up to 24 months after MRgFUSth treatment. Participants will undergo a suprathreshold levodopa test and ¹⁸F-DOPA PET imaging to evaluate dopaminergic and serotonergic involvement in tremor. All participants will receive MRgFUSth and be followed for 24 months with standardized clinical, cognitive, and quality-of-life assessments. The study seeks to improve understanding the possible mechanisms of tremor relapse and inform patient selection for MRgFUSth in PD.
Official title: Predictors and Mechanisms of Tremor Relapse After MR-Guided Focused Ultrasound Thalamotomy in Parkinson's Disease
Key Details
Gender
All
Age Range
50 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-12-01
Completion Date
2029-02
Last Updated
2026-01-07
Healthy Volunteers
No
Conditions
Interventions
MR-guided focused ultrasound thalamotomy
MR-guided focused ultrasound thalamotomy of the ventral intermediate nucleus of the thalamus
Locations (1)
Aarhus University Hospital
Aarhus, Denmark