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Efficacy and Safety of Ribupatide Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
Sponsor: Kailera
Summary
The primary objective of this study is to demonstrate that ribupatide (KAI-9531) subcutaneous (SC) injection once weekly is superior to placebo on: * Percent change in body weight * Change in hemoglobin A1c (HbA1c)
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of KAI-9531 Administered Once Weekly in Participants Living With Obesity or Overweight and Diabetes
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1156
Start Date
2026-01-12
Completion Date
2028-04-24
Last Updated
2026-07-15
Healthy Volunteers
No
Interventions
Ribupatide
SC Injection
Placebo
SC Injection
Locations (116)
Kailera Clinical Site
Cullman, Alabama, United States
Kailera Clinical Site
Phoenix, Arizona, United States
Kailera Clinical Site
Sun City, Arizona, United States
Kailera Clinical Site
Little Rock, Arkansas, United States
Kailera Clinical Site
Escondido, California, United States
Kailera Clinical Site
Montclair, California, United States
Kailera Clinical Site
Northridge, California, United States
Kailera Clinical Site
Oceanside, California, United States
Kailera Clinical Site
Toluca Lake, California, United States
Kailera Clinical Site
Stamford, Connecticut, United States
Kailera Clinical Site
Jupiter, Florida, United States
Kailera Clinical Site
Miami, Florida, United States
Kailera Clinical Site
Orange City, Florida, United States
Kailera Clinical Site
Orlando, Florida, United States
Kailera Clinical Site
Orlando, Florida, United States
Kailera Clinical Site
The Villages, Florida, United States
Kailera Clinical Site
Lilburn, Georgia, United States
Kailera Clinical Site
Skokie, Illinois, United States
Kailera Clinical Site
Springfield, Illinois, United States
Kailera Clinical Site
Newton, Kansas, United States
Kailera Clinical Site
Shreveport, Louisiana, United States
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Columbia, Maryland, United States
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Farmington Hills, Michigan, United States
Kailera Clinical Site
Missoula, Montana, United States
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Lincoln, Nebraska, United States
Kailera Clinical Site
Las Vegas, Nevada, United States
Kailera Clinical Site
Albany, New York, United States
Kailera Clinical Site
Laurelton, New York, United States
Kailera Clinical Site
Greensboro, North Carolina, United States
Kailera Clinical Site
Morehead City, North Carolina, United States
Kailera Clinical Site
Chickasha, Oklahoma, United States
Kailera Clinical Site
Spartanburg, South Carolina, United States
Kailera Clinical Site
Chattanooga, Tennessee, United States
Kailera Clinical Site
Amarillo, Texas, United States
Kailera Clinical Site
Brownsville, Texas, United States
Kailera Clinical Site
DeSoto, Texas, United States
Kailera Clinical Site
Tomball, Texas, United States
Kailera Clinical Site
Pleasant View, Utah, United States
Kailera Clinical Site
Salt Lake City, Utah, United States
Kailera Clinical Site
Manassas, Virginia, United States
Kailera Clinical Site
Richmond, Virginia, United States
Kailera Clinical Site
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Kailera Clinical Site
Mar del Plata, Buenos Aires, Argentina
Kailera Clinical Site
San Nicolás de los Arroyos, Buenos Aires, Argentina
Kailera Clinical Site
Zárate, Buenos Aires, Argentina
Kailera Clinical Site
Buenos Aires, Buenos Aires F.D., Argentina
Kailera Clinical Site
Godoy Cruz, Mendoza Province, Argentina
Kailera Clinical Site
Rosario, Sante Fe, Argentina
Kailera Clinical Site
CABA, Argentina
Kailera Clinical Site
Córdoba, Argentina
Kailera Clinical Site
Bruce, Australian Capital Territory, Australia
Kailera Clinical Site
Blacktown, New South Wales, Australia
Kailera Clinical Site
Kanwal, New South Wales, Australia
Kailera Clinical Site
Leichhardt, New South Wales, Australia
Kailera Clinical Site
Sydney, New South Wales, Australia
Kailera Clinical Site
Sydney, New South Wales, Australia
Kailera Clinical Site
Wollongong, New South Wales, Australia
Kailera Clinical Site
Herston, Queensland, Australia
Kailera Clinical Site
Morayfield, Queensland, Australia
Kailera Clinical Site
Camberwell, Victoria, Australia
Kailera Clinical Site
Melbourne, Victoria, Australia
Kailera Clinical Site
South Brisbane, Australia
Kailera Clinical Site
Kyustendil, Kyustendil Province, Bulgaria
Kailera Clinical Site
Pleven, Pleven Province, Bulgaria
Kailera Clinical Site
Plovdiv, Plovdiv Province, Bulgaria
Kailera Clinical Site
Rousse, Ruse Province, Bulgaria
Kailera Clinical Site
Sofia, Sofia, Bulgaria
Kailera Clinical Site
Sofia, Sofia, Bulgaria
Kailera Clinical Site
Stara Zagora, Stara Zagora Province, Bulgaria
Kailera Clinical Site
Varna, Varna Province, Bulgaria
Kailera Clinical Site
Montana, Bulgaria
Kailera Clinical Site
Brandýs nad Labem, Central Bohemia, Czechia
Kailera Clinical Site
Náchod, Hradec Králové Region, Czechia
Kailera Clinical Site
Trutnov, Hradec Králové Region, Czechia
Kailera Clinical Site
Brno, South Moravian, Czechia
Kailera Clinical Site
Holešov, Zlín, Czechia
Kailera Clinical Site
Hodonín, Czechia
Kailera Clinical Site
Pardubice, Czechia
Kailera Clinical Site
Uherské Hradiště, Czechia
Kailera Clinical Site
Falkensee, Brandenburg, Germany
Kailera Clinical Site
Cologne, North Rhine-Westphalia, Germany
Kailera Clinical Site
Essen, North Rhine-Westphalia, Germany
Kailera Clinical Site
Oldenburg in Holstein, Schleswig-Holstein, Germany
Kailera Clinical Site
Schwerin, Germany
Kailera Clinical Site
Grafton, Auckland, New Zealand
Kailera Clinical Site
New Lynn, Auckland, New Zealand
Kailera Clinical Site
Silverdale, Auckland, New Zealand
Kailera Clinical Site
Takapuna, Auckland, New Zealand
Kailera Clinical Site
Nawton, Hamilton, New Zealand
Kailera Clinical Site
Auckland, New Zealand
Kailera Clinical Site
Hastings, New Zealand
Kailera Clinical Site
Nelson, New Zealand
Kailera Clinical Site
Torun, Kuyavian-Pomeranian Voivodeship, Poland
Kailera Clinical Site
Krakow, Lesser Poland Voivodeship, Poland
Kailera Clinical Site
Siedlce, Masovian Voivodeship, Poland
Kailera Clinical Site
Warsaw, Masovian Voivodeship, Poland
Kailera Clinical Site
Gdynia, Pomeranian Voivodeship, Poland
Kailera Clinical Site
Chorzów, Silesian Voivodeship, Poland
Kailera Clinical Site
Gdynia, Poland
Kailera Clinical Site
Krakow, Poland
Kailera Clinical Site
Warsaw, Poland
Kailera Clinical Site
Skierniewice, Łódź Voivodeship, Poland
Kailera Clinical Site
Kielce, Świętokrzyskie Voivodeship, Poland
Kailera Clinical Site
San Juan, Puerto Rico
Kailera Clinical Site
Ferrol, A Coruna, Spain
Kailera Clinical Site
Villamartín, Cadiz, Spain
Kailera Clinical Site
Madrid, Spain
Kailera Clinical Site
Valencia, Spain
Kailera Clinical Site
Truro, Cornwall, United Kingdom
Kailera Clinical Site
Hull, East Yorkshire, United Kingdom
Kailera Clinical Site
London, Greater London, United Kingdom
Kailera Clinical Site
Leicester, Leicestershire, United Kingdom
Kailera Clinical Site
Nottingham, Nottinghamshire, United Kingdom
Kailera Clinical Site
Yate, South Gloucestershire, United Kingdom
Kailera Clinical Site
Bradford, West Yorkshire, United Kingdom
Kailera Clinical Site
Manchester, United Kingdom