Clinical Research Directory

Inclusion Criteria: 1. Aged 18 to 70 years (inclusive), irrespective of sex and race. 2. Life expectancy greater than 12 weeks. 3. Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 to 2. 4. Meets the National Comprehensive Cancer Network (NCCN) criteria for relapsed or refractory disease, with a confirmed diagnosis of CD19-positive hematolymphoid malignancy 5. Adequate hepatic, renal, and cardiopulmonary function 6. Absolute lymphocyte count (ALC) ≥ 0.5 × 10⁹/L; Platelet count ≥ 50 × 10⁹/L; CD3-positive T-cell count ≥ 150 cells/μL Exclusion Criteria: 1. Patients who, in the investigator's judgment at screening, require long-term use of immunosuppressive agents. 2. History of cerebrovascular accident or convulsive seizures within 6 months prior to signing the informed consent form. 3. Presence of other active malignant diseases besides the disease under study, with the exception of carcinoma in situ. 4. Patients with severe cardiac disease, unstable systemic diseases, or chronic progressive neurological disorders, etc. 5. Patients who have received CAR-T therapy or other genetically modified cell therapies prior to screening. 6. Patients who have participated in other clinical studies within 1 month prior to screening. 7. Evidence of central nervous system involvement at the time of screening.