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Histamines and Central Hemodynamics
Sponsor: University of British Columbia
Summary
When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.
Official title: The Role of Histamines on Central Hemodynamics
Key Details
Gender
All
Age Range
19 Years - 39 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2025-12
Completion Date
2026-08
Last Updated
2025-12-23
Healthy Volunteers
Yes
Interventions
Diphenhydramine hydrochloride
H1 receptor antagonist: 50mg Diphenhydramine Hydrochloride
Placebo
Placebo
Exercise Bout
Participants will complete a total of three 5-minute high intensity exercise intervals, interspersed with 5-minute lower intensity exercise bouts (4 total), for a total of 35 minutes.
Locations (1)
University of British Columbia
Kelowna, British Columbia, Canada