Clinical Research Directory

Inclusion Criteria: * Type 1 diabetes for \> 5 years. * Age between 18-60 years. * HbA1c ≤ 8.5%. * Body mass index between 18 and 30 kg/m². * Physically active (≥ 4 hours/week of exercise). * Laboratory data and EKG without alterations of the last 12 months. * Valid Type 2 sports medical examination, which includes a monitored stress test with continuous ECG and blood pressure monitoring, as well as an official medical certificate confirming fitness to participate in this study. * Experience using CGM sensors and be used to self-monitor blood glucose and carbohydrate counting. Exclusion Criteria: * Unable to ride gravel bikes. * Unable to use clipless pedals. * Pregnancy and breastfeeding. * Hypoglycemia unawareness (Clarke Test \> 3). * Severe hypoglycemia in the previous 6 monhts. * Progressive fatal disease. * History of drug or alcohol abuse. * Impaired liver function. * Clinically relevant microvascular complications (macroalbuminuria, pre-proliferative and proliferative retinopathy), cardiovascular, hepatic, neurological, endocrine or other systemic disease, apart from T1D. * Mental conditions that prevent the subject from understanding the nature, purpose and possible consequences of the study. * Using an experimental drug or device during the prior 30 days. Inclusion (healthy control group): adults 18-60 years without diabetes and physically active (≥ 4 hours/week of exercise) who can provide pre/post saliva and uringe samples for omics analyses.