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Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
Sponsor: Istituto Ortopedico Rizzoli
Summary
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups. Cardiopulmonary complications are recognized as major contributors to morbidity and mortality in adults with OI, although life expectancy has significantly improved in recent years due to medical advancements. By systematically evaluating cardiovascular involvement in this population, the study aims to generate clinically relevant evidence to inform early cardiologic screening strategies and support the development of harmonized and targeted management approaches, ultimately improving clinical practice and the quality of life of individuals living with OI.
Official title: Evaluation of Cardiac Function and Morphology in Individuals With Osteogenesis Imperfecta: Prospective Observational Study
Key Details
Gender
All
Age Range
5 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2025-06-10
Completion Date
2031-12
Last Updated
2025-12-17
Healthy Volunteers
No
Interventions
Imaging evaluation, Echocardiography
Since this is an observational study, researchers collect general information from instrumental investigations and functional assessments carried out as part of normal clinical practice
Locations (1)
IRCCS Istituto Ortopedico Rizzoli
Bologna, Emilia-Romagna, Italy